As the 2025 NFL season starts tonight, 13 players who competed in either the Big South Conference or the Ohio Valley Conference find themselves on NFL rosters for the season. That number includes eight active players, four practice squad members and one on PUP/injured reserve/suspended as of September 3.

Active (8)
Joe Andreessen, Buffalo Bills (Bryant)
Mike Ford, Atlanta Falcons (Southeast Missouri)
Jimmy Garoppolo, Los Angeles Rams (Eastern Illinois)
Julian Hill, Miami Dolphins (Campbell)
Siran Neal, San Francisco 49ers (Jacksonville State) 
Khalen Saunders, Jacksonville Jaguars (Western Illinois) **
Quincy Williams, New York Jets (Murray State)
Rock Ya-Sin, Detroit Lions (Presbyterian)

PUP/IR (1)
Gareth Warren, Pittsburgh Steelers (Lindenwood)

Practice Squad (4)
Ryan Flournoy, Dallas Cowboys (Southeast Missouri)
Ricky Lee, Jacksonville Jaguars (North Carolina A&T)
Mark Robinson, New England Patriots (Southeast Missouri)
Kristian Wilkerson, Buffalo Bills (Southeast Missouri)

Head Coaches
Sean Payton, Denver Broncos (Eastern Illinois)

** Went to Western Illinois prior to them joining the OVC-Big South Football Association.